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The book covering most challenging aspects of COVID-19 with some different changes between both waves has 33 chapters. The contributors have tried to include latest & authentic contents to maintain the sanctity & standards of this book. This book will be a valuable resource for all the Physicians & Doctors working with COVID-19 patients in their day-to-day practice. This new edition of “COVID-19: SECOND WAVE IN INDIA — HOW DIFFERENT FROM FIRST” is being published with the theme of “If nothing is sure, Everything is possible” to the harness the indigenous talent of our country which will be empowering medicine globally. Therefore, the book contains articles from deyons of medicine of the country. The year 2020 & major portion of 2021 have been historical which have seen the entire world fighting against a virus which can be easily washed away by soap & water. Yet the enthusiasm shown by contributors for this book on COVID-19 itself has been exemplary & praiseworthy.